We exist for one reason – to grant magical wishes to enrich the lives of children and young people fighting life-threatening conditions. Because a child’s life shouldn’t be about illness, hospitals and diagnosis – it should be about wonder, joy and hope.

Taking on a challenge like this calls for a special type of dedication. And that's something we know all about. Our teams work round the clock in the toughest places on the planet to save the lives of the world's most vulnerable children. It's intense, exhausting work – but giving up simply isn't an option. Are you ready to do whatever it takes to help? Then sign up to run for us today.

With more than 268,000 patient visits every year, we need your support to help us give hope to our young patients and their families.

Cancer Research UK is the world's leading charity dedicated to research on the causes, treatment and prevention of cancer.

Run to save the lives of people with blood cancer, including leukaemia and lymphoma. Join the team and you can help us provide lifesaving stem cell transplants to patients in need.

Our vision is a world in which people do not die prematurely or suffer from heart disease. Thanks to you, we’ve made great progress. With you, we’ll beat it.

Macmillan Cancer Support improves the lives of people affected by cancer. We provide practical, medical, emotional and financial support and push for better cancer care. Cancer affects us all. We can all help. We are Macmillan.

At SSAFA we provide practical, emotional and financial support to current and former members of the Armed Forces and their families. Every year we support 90,000 people across the UK and in 14 countries around the world. Take on a Tough Mudder to make a difference for our Forces and their families.

We will not rest until people who are blind or partially sighted can enjoy the same freedom of movement as everyone else.

If you have your own place please get in touch. We currently have no charity places available but you can apply to join the reserve list! Children with Cancer UK is the leading national charity dedicated to the fight against childhood cancer. Our aim is to determine the causes, find cures and provide care for children with cancer.

Together, we are strong enough to stop MS. We understand what life’s like with MS, and we support each other through the highs, lows and everything in between.

Around 225,000 people develop dementia every year – that’s the equivalent to one person every three minutes. Join Team Alzheimer’s Society and help us improve the quality of life for people living with dementia now, and to find a cure for the future.

We help children who’ve been abused to rebuild their lives, we protect children at risk, and we find the best ways of preventing child abuse from ever happening. Run for Team NSPCC, because every step, every mile, will help keep every child safe.

We're Mind, the mental health charity. We won't give up until everyone experiencing a mental health problem gets both support and respect. Help us change lives, support us today.

Sense is a national charity that supports people who are deafblind, have sensory impairments or complex needs, to enjoy more independent lives.